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Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment
Cancer cells take up amino acids from the extracellular space to drive cell proliferation and viability. Similar mechanisms are applied by immune cells, resulting in the competition between conventional T cells, or indeed chimeric antigen receptor (CAR) T cells and tumor cells, for the limited avail...
Autores principales: | Panetti, Silvia, McJannett, Nicola, Fultang, Livingstone, Booth, Sarah, Gneo, Luciana, Scarpa, Ugo, Smith, Charles, Vardon, Ashley, Vettore, Lisa, Whalley, Celina, Pan, Yi, Várnai, Csilla, Endou, Hitoshi, Barlow, Jonathan, Tennant, Daniel, Beggs, Andrew, Mussai, Francis, De Santo, Carmela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Hematology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182289/ https://www.ncbi.nlm.nih.gov/pubmed/36521029 http://dx.doi.org/10.1182/bloodadvances.2022008272 |
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