Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays

In next generation risk assessment (NGRA), the Dietary Comparator Ratio (DCR) can be used to assess the safety of chemical exposures to humans in a 3R compliant approach. The DCR compares the Exposure Activity Ratio (EAR) for exposure to a compound of interest (EAR(test)) to the EAR for an establish...

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Detalles Bibliográficos
Autores principales: van Tongeren, Tessa C. A., Wang, Si, Carmichael, Paul L., Rietjens, Ivonne M. C. M., Li, Hequn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Regulatory Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182946/
https://www.ncbi.nlm.nih.gov/pubmed/37087486
http://dx.doi.org/10.1007/s00204-023-03480-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182946/
https://www.ncbi.nlm.nih.gov/pubmed/37087486
http://dx.doi.org/10.1007/s00204-023-03480-w

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