Cargando…

Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays

In next generation risk assessment (NGRA), the Dietary Comparator Ratio (DCR) can be used to assess the safety of chemical exposures to humans in a 3R compliant approach. The DCR compares the Exposure Activity Ratio (EAR) for exposure to a compound of interest (EAR(test)) to the EAR for an establish...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Tongeren, Tessa C. A., Wang, Si, Carmichael, Paul L., Rietjens, Ivonne M. C. M., Li, Hequn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Regulatory Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182946/ https://www.ncbi.nlm.nih.gov/pubmed/37087486 http://dx.doi.org/10.1007/s00204-023-03480-w

Ejemplares similares

Next Generation Risk Assessment of the Anti-Androgen Flutamide Including the Contribution of Its Active Metabolite Hydroxyflutamide
por: van Tongeren, Tessa C.A., et al.
Publicado: (2022)

New aspects in deriving health-based guidance values for bromate in swimming pool water
por: Röhl, C., et al.
Publicado: (2022)

Extended evaluation on the ES-D3 cell differentiation assay combined with the BeWo transport model, to predict relative developmental toxicity of triazole compounds
por: Li, Hequn, et al.
Publicado: (2015)

Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety
por: Borgert, C. J., et al.
Publicado: (2021)

A new approach to the classification of carcinogenicity
por: Doe, John E., et al.
Publicado: (2022)

Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model
por: Tonnelier, Arnaud, et al.
Publicado: (2011)

Sensory irritation as a basis for setting occupational exposure limits
por: Brüning, Thomas, et al.
Publicado: (2014)

Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods
por: Casati, S., et al.
Publicado: (2017)

Predicting in vivo effect levels for repeat-dose systemic toxicity using chemical, biological, kinetic and study covariates
por: Truong, Lisa, et al.
Publicado: (2017)

Current pesticide dietary risk assessment in light of comparable animal study NOAELs after chronic and short-termed exposure durations
por: Zarn, Jürg A., et al.
Publicado: (2017)

A framework for the use of single-chemical transcriptomics data in predicting the hazards associated with complex mixtures of polycyclic aromatic hydrocarbons
por: Labib, Sarah, et al.
Publicado: (2016)

Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment
por: Farmahin, Reza, et al.
Publicado: (2016)

Screening of repeated dose toxicity data in safety evaluation reports of cosmetic ingredients issued by the Scientific Committee on Consumer Safety between 2009 and 2019
por: Gustafson, Emma, et al.
Publicado: (2020)

Investigating the effects of differently produced synthetic amorphous silica (E 551) on the integrity and functionality of the human intestinal barrier using an advanced in vitro co-culture model
por: Hempt, Claudia, et al.
Publicado: (2020)

Application of grouping and read-across for the evaluation of parabens of different chain lengths with a particular focus on endocrine properties
por: Fayyaz, Susann, et al.
Publicado: (2021)

A framework for chemical safety assessment incorporating new approach methodologies within REACH
por: Ball, Nicholas, et al.
Publicado: (2022)

Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment
por: Madia, Federica, et al.
Publicado: (2021)

“Don’t Blast”: blast-in-place (BiP) operations of dumped World War munitions in the oceans significantly increase hazards to the environment and the human seafood consumer
por: Maser, Edmund, et al.
Publicado: (2020)

An approach for mixture testing and prioritization based on common kinetic groups
por: Braeuning, Albert, et al.
Publicado: (2022)

A new conceptional model for deriving average dermal absorption estimates from studies with multiple tested concentrations for non-dietary risk assessment of pesticides
por: Kluxen, Felix M., et al.
Publicado: (2022)

Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data
por: Najjar, Abdulkarim, et al.
Publicado: (2022)

Species differences and human relevance of the toxicity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors and a new approach method in vitro for investigation
por: Botham, Jane, et al.
Publicado: (2023)

A mixture of 13 pesticides, contaminants, and food additives below individual NOAELs produces histopathological and organ weight changes in rats
por: Dinca, Viorica, et al.
Publicado: (2023)

Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
por: Escher, Beate I., et al.
Publicado: (2023)

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology
por: Botham, Philip, et al.
Publicado: (2023)

Oral nicotine pouches with an aftertaste? Part 1: screening and initial toxicological assessment of flavorings and other ingredients
por: Mallock-Ohnesorg, Nadja, et al.
Publicado: (2023)

Oral nicotine pouches with an aftertaste? Part 2: in vitro toxicity in human gingival fibroblasts
por: Rinaldi, Selina, et al.
Publicado: (2023)

Development of a Generic Physiologically Based Kinetic Model to Predict In Vivo Uterotrophic Responses Induced by Estrogenic Chemicals in Rats Based on In Vitro Bioassays
por: Zhang, Mengying, et al.
Publicado: (2020)

DMSO Concentrations up to 1% are Safe to be Used in the Zebrafish Embryo Developmental Toxicity Assay
por: Hoyberghs, Jente, et al.
Publicado: (2021)

Next Generation Reproductive and Developmental Toxicology: Crosstalk Into the Future
por: Hougaard, Karin Sørig
Publicado: (2021)

Mentoring and Supporting Our Next Generation of Women Toxicologists
por: Swanson, Hollie I.
Publicado: (2022)

Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing
por: Rajagopal, Ramya, et al.
Publicado: (2022)

Drug Lag and Key Regulatory Barriers in the Emerging Markets
por: Wileman, Harriet, et al.
Publicado: (2010)

Regulations and guidelines governing stem cell based products: Clinical considerations
por: George, Bobby
Publicado: (2011)

Regulatory Considerations for Biosimilars
por: Nellore, Ranjani
Publicado: (2010)

Registration of Medical Devices
por: George, Bobby
Publicado: (2010)

Implications of ICH-E5: Assessment of drug's sensitivity to ethnic factors and necessity of a bridging study for global drug development
por: Gupta, Sandeep Kumar
Publicado: (2011)

Regulatory requirements for marketing fixed dose combinations
por: Jayasheel, B. G.
Publicado: (2010)

Injury and death in clinical trials and compensation: Rule 122 DAB
por: Ghooi, Ravindra. B.
Publicado: (2013)

Key points of technical review for the registration of SARS-CoV-2 antigen/antibody tests
por: Li, Hongran, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ammkd6912brpfiqvl3f65hup91