Cargando…

A new cell line based coculture system for skin sensitisation testing in one single assay using T cells, aryl hydrocarbon receptor knockout, and co-inhibitory blockage

Established in vitro assays for regulatory testing of skin sensitisation partly suffer from only moderate sensitivity, specificity, and predictivity when testing specific groups of chemicals. This may be due to limited biomarker response in vitro in cell types that interact as crucial players of in...

Descripción completa

Detalles Bibliográficos
Autores principales: Sonnenburg, Anna, Stahlmann, Ralf, Kreutz, Reinhold, Peiser, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182954/
https://www.ncbi.nlm.nih.gov/pubmed/37147507
http://dx.doi.org/10.1007/s00204-023-03506-3