Functional variants identify sex-specific genes and pathways in Alzheimer’s Disease

The incidence of Alzheimer’s Disease in females is almost double that of males. To search for sex-specific gene associations, we build a machine learning approach focused on functionally impactful coding variants. This method can detect differences between sequenced cases and controls in small cohor...

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Detalles Bibliográficos
Autores principales: Bourquard, Thomas, Lee, Kwanghyuk, Al-Ramahi, Ismael, Pham, Minh, Shapiro, Dillon, Lagisetty, Yashwanth, Soleimani, Shirin, Mota, Samantha, Wilhelm, Kevin, Samieinasab, Maryam, Kim, Young Won, Huh, Eunna, Asmussen, Jennifer, Katsonis, Panagiotis, Botas, Juan, Lichtarge, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183026/
https://www.ncbi.nlm.nih.gov/pubmed/37179358
http://dx.doi.org/10.1038/s41467-023-38374-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183026/
https://www.ncbi.nlm.nih.gov/pubmed/37179358
http://dx.doi.org/10.1038/s41467-023-38374-z

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