Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment

Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid–liquid phase separation, ribosome biogenesis, chape...

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Detalles Bibliográficos
Autores principales: Sekhar, Konjeti R., Freeman, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183826/
https://www.ncbi.nlm.nih.gov/pubmed/36877156
http://dx.doi.org/10.1158/0008-5472.CAN-22-3631
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author Sekhar, Konjeti R.
Freeman, Michael L.
author_facet Sekhar, Konjeti R.
Freeman, Michael L.
author_sort Sekhar, Konjeti R.
collection PubMed
description Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid–liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically Polη-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment.
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spelling pubmed-101838262023-05-16 Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment Sekhar, Konjeti R. Freeman, Michael L. Cancer Res Reviews Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid–liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically Polη-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment. American Association for Cancer Research 2023-05-15 2023-03-06 /pmc/articles/PMC10183826/ /pubmed/36877156 http://dx.doi.org/10.1158/0008-5472.CAN-22-3631 Text en ©2023 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
spellingShingle Reviews
Sekhar, Konjeti R.
Freeman, Michael L.
Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
title Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
title_full Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
title_fullStr Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
title_full_unstemmed Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
title_short Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
title_sort nucleophosmin plays a role in repairing dna damage and is a target for cancer treatment
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183826/
https://www.ncbi.nlm.nih.gov/pubmed/36877156
http://dx.doi.org/10.1158/0008-5472.CAN-22-3631
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