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KNO1‐mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination

Homologous recombination (HR) is a key DNA damage repair pathway that is tightly adjusted to the state of a cell. A central regulator of homologous recombination is the conserved helicase‐containing Bloom syndrome complex, renowned for its crucial role in maintaining genome integrity. Here, we show...

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Detalles Bibliográficos
Autores principales: Chen, Poyu, De Winne, Nancy, De Jaeger, Geert, Ito, Masaki, Heese, Maren, Schnittger, Arp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183828/
https://www.ncbi.nlm.nih.gov/pubmed/36970874
http://dx.doi.org/10.15252/embj.2022111980