Cargando…

Convergent synthesis, kinetics insight and allosteric computational ascriptions of thiazole-(5-aryl)oxadiazole hybrids embraced with propanamides as alkaline phosphatase inhibitors

Considering the varied pharmacological prominence of thiazole and oxadiazole heterocyclic moieties, a unique series of bi-heterocyclic hybrids, 8a–h, was synthesized in a convergent manner. The structures of newly synthesized compounds were characterized by (1)H-NMR, (13)C-NMR, and IR spectral studi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Butt, Abdul Rehman Sadiq, Abbasi, Muhammad Athar, Aziz-ur-Rehman, Siddiqui, Sabahat Zahra, Muhammad, Shabbir, Raza, Hussain, Shah, Syed Adnan Ali, Shahid, Muhammad, Alsehemi, Abdullah G., Kim, Song Ja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184136/ https://www.ncbi.nlm.nih.gov/pubmed/37197574 http://dx.doi.org/10.1039/d3ra01348k

Ejemplares similares

Novel Bi-heterocycles as Potent Inhibitors of Urease and Less Cytotoxic Agents: 3-({5-((2-Amino-1,3-thiazol-4-yl)methyl)-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(un/substituted-phenyl)propanamides
por: Abbasi, Muhammad Athar, et al.
Publicado: (2020)

Synthesis and Molecular Docking Studies of Novel Biheterocyclic Propanamides as Antidiabetic Agents Having Mild Cytotoxicity
por: Abbasi, Muhammad Athar, et al.
Publicado: (2023)

Modular and Computational Access to Innocuous Multistep Metal-Free Synthesis of 1,3,4-Oxadiazoles as Enzyme Inhibitors
por: Umair, Muhammad, et al.
Publicado: (2023)

Novel indole based hybrid oxadiazole scaffolds with N-(substituted-phenyl)butanamides: synthesis, lineweaver–burk plot evaluation and binding analysis of potent urease inhibitors
por: Nazir, Majid, et al.
Publicado: (2018)

Synthesis, Kinetics, Binding Conformations and Structure-activity Relationship of Potent Tyrosinase Inhibitors: Aralkylated 2-aminothiazole-ethyltriazole Hybrids
por: Sadiq Butt, Abdul Rehman, et al.
Publicado: (2021)

Selene-Ethylenelacticamides and N-Aryl-Propanamides as Broad-Spectrum Leishmanicidal Agents
por: de Sousa, Natália Ferreira, et al.
Publicado: (2023)

Collective-Goal Ascription Increases Cooperation in Humans
por: Mitkidis, Panagiotis, et al.
Publicado: (2013)

Synthesis and exploration of a novel chlorobenzylated 2-aminothiazole-phenyltriazole hybrid as migratory inhibitor of B16F10 in melanoma cells
por: Athar Abbasi, Muhammad, et al.
Publicado: (2019)

Responsibility Ascriptions in Technology Development and Engineering: Three Perspectives
por: Doorn, Neelke
Publicado: (2009)

The Merit of Ascription? Economic Elite Perceptions of Inheritance Taxation
por: Atria, Jorge
Publicado: (2022)

Theory of mind: a new perspective on the puzzle of belief ascription
por: Airenti, Gabriella
Publicado: (2015)

Minimal Organizational Requirements for the Ascription of Animal Personality to Social Groups
por: Japyassú, Hilton F., et al.
Publicado: (2021)

Preliminary Anticonvulsant and Toxicity Screening of Substituted Benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides
por: Ali, Ruhi, et al.
Publicado: (2014)

Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles
por: Ibrar, Aliya, et al.
Publicado: (2018)

Knowledge before belief ascription? Yes and no (depending on the type of “knowledge” under consideration)
por: Rakoczy, Hannes, et al.
Publicado: (2022)

Synthesis, enzyme inhibitory kinetics mechanism and computational study of N-(4-methoxyphenethyl)-N-(substituted)-4-methylbenzenesulfonamides as novel therapeutic agents for Alzheimer’s disease
por: Abbasi, Muhammad Athar, et al.
Publicado: (2018)

Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis
por: Martinez-Grau, Maria Angeles, et al.
Publicado: (2018)

Corrigendum: Knowledge before belief ascription? Yes and no (depending on the type of “knowledge” under consideration)
por: Rakoczy, Hannes, et al.
Publicado: (2022)

2-Cyano-2-methylpropanamide
por: Xu, Jia-Ying, et al.
Publicado: (2012)

Molecular Docking, Computational, and Antithrombotic Studies of Novel 1,3,4-Oxadiazole Derivatives
por: Batool, Majda, et al.
Publicado: (2018)

Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones
por: Weng, Jian-Quan, et al.
Publicado: (2012)

Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles
por: Desai, N.C., et al.
Publicado: (2013)

N-{2-[N-(4-Methylphenyl)oxamoyl]phenyl}propanamide
por: Pervez, Humayun, et al.
Publicado: (2010)

Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their in silico studies
por: Ahmad, Saghir, et al.
Publicado: (2023)

Lipid stability, antioxidant potential and fatty acid composition of broilers breast meat as influenced by quercetin in combination with α-tocopherol enriched diets
por: Sohaib, Muhammad, et al.
Publicado: (2015)

Decoding RNA Editing Sites Through Transcriptome Analysis in Rice Under Alkaline Stress
por: Rehman, Obaid, et al.
Publicado: (2022)

N-tert-Butyl-2-methylpropanamide
por: Kluge, Kelly A., et al.
Publicado: (2011)

1-Chloromethyl-3-nitrobenzene
por: Abbasi, Muhammad Athar, et al.
Publicado: (2010)

1-Chloromethyl-4-nitrobenzene
por: Aziz-ur-Rehman,, et al.
Publicado: (2010)

N-(3-Ethoxyphenyl)-4-methylbenzenesulfonamide
por: Aziz-ur-Rehman,, et al.
Publicado: (2010)

6-Hydroxymethyl-4-methoxy-2H-pyran-2-one (Opuntiol)
por: Abbasi, Muhammad Athar, et al.
Publicado: (2009)

N-(5-Chloro-2-methoxyphenyl)benzenesulfonamide
por: Aziz-ur-Rehman,, et al.
Publicado: (2010)

Investigation of Novel Benzoxazole-Oxadiazole Derivatives as Effective Anti-Alzheimer’s Agents: In Vitro and In Silico Approaches
por: Anwar, Saeed, et al.
Publicado: (2023)

Ammonium [(1S)-(endo,anti)]-(−)-3-bromocamphor-8-sulfonate
por: Abbasi, Muhammad Athar, et al.
Publicado: (2010)

N-(2-Methoxyphenyl)benzenesulfonamide
por: Aziz-ur-Rehman,, et al.
Publicado: (2010)

Synthesis of Brominated 2-Phenitidine Derivatives as Valuable Inhibitors of Cholinesterases for the Treatment of Alzheimer’s Disease
por: Abbasi, Muhammad Athar, et al.
Publicado: (2014)

N-tert-Butyl-2-methylpropanamide. Corrigendum
por: Kluge, Kelly A., et al.
Publicado: (2011)

N-(2-Methylphenylsulfonyl)propanamide
por: Shakuntala, K., et al.
Publicado: (2011)

3-Chloro-N-(4-sulfamoylphenyl)propanamide
por: Akkurt, Mehmet, et al.
Publicado: (2010)

Synthesis of amantadine clubbed N-aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies
por: Zahra, Fatima Tuz, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_90nem4l1dk2h9rbj63vf3a62pc