Cargando…

Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm

BACKGROUND AND OBJECTIVES: Phenotypic switching in vascular smooth muscle cells (VSMCs) has been linked to aortic aneurysm, but the phenotypic landscape in aortic aneurysm is poorly understood. The present study aimed to analyse the phenotypic landscape, phenotypic differentiation trajectory, and po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Genmao, Xuan, Xuezhen, Li, Yaling, Hu, Jie, Zhang, Ruijing, Jin, Haijiang, Dong, Honglin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184349/ https://www.ncbi.nlm.nih.gov/pubmed/37189183 http://dx.doi.org/10.1186/s12964-023-01120-5

Ejemplares similares

How vascular smooth muscle cell phenotype switching contributes to vascular disease
por: Cao, Genmao, et al.
Publicado: (2022)

Deciphering the Intercellular Communication Between Immune Cells and Altered Vascular Smooth Muscle Cell Phenotypes in Aortic Aneurysm From Single-Cell Transcriptome Data
por: Cao, Genmao, et al.
Publicado: (2022)

Gene Therapy for Cardiovascular Disease: Basic Research and Clinical Prospects
por: Cao, Genmao, et al.
Publicado: (2021)

Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms
por: Clément, Marc, et al.
Publicado: (2019)

Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms
por: Lu, Haocheng, et al.
Publicado: (2021)

The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections
por: Rombouts, Karlijn B., et al.
Publicado: (2021)

Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm
por: Gurung, Rijan, et al.
Publicado: (2020)

TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
por: Wang, Jing, et al.
Publicado: (2022)

Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells
por: Qian, Guoqing, et al.
Publicado: (2022)

The Role and Mechanism of SIRT6 in Regulating Phenotype Transformation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm
por: Guan, Xiaomei, et al.
Publicado: (2022)

Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms
por: Malashicheva, Anna, et al.
Publicado: (2016)

Defective autophagy in vascular smooth muscle cells enhances the healing of abdominal aortic aneurysm
por: Mochida, Akihiro, et al.
Publicado: (2021)

PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm
por: Wang, Zhenguo, et al.
Publicado: (2023)

Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms
por: Gomez, Delphine, et al.
Publicado: (2011)

CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells
por: He, Xiang, et al.
Publicado: (2021)

miR‐145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection
por: Qiu, Zhi‐Huang, et al.
Publicado: (2021)

Phenotypic Modulation of Cultured Primary Human Aortic Vascular Smooth Muscle Cells by Uremic Serum
por: Cazaña-Pérez, Violeta, et al.
Publicado: (2018)

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
por: Malhotra, Rajeev, et al.
Publicado: (2019)

Protective Role for Smooth Muscle Cell Hepcidin in Abdominal Aortic Aneurysm
por: Loick, Paul, et al.
Publicado: (2023)

A reduction in the vascular smooth muscle cell focal adhesion component syndecan‐4 is associated with abdominal aortic aneurysm formation
por: Hu, Jiaxin, et al.
Publicado: (2021)

IL-37 Expression in Patients with Abdominal Aortic Aneurysm and Its Role in the Necroptosis of Vascular Smooth Muscle Cells
por: Ding, Yan, et al.
Publicado: (2022)

Mitochondrial Dysfunction and Increased DNA Damage in Vascular Smooth Muscle Cells of Abdominal Aortic Aneurysm (AAA-SMC)
por: Tavris, Bengi S., et al.
Publicado: (2023)

Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm
por: Riches, Kirsten, et al.
Publicado: (2013)

TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm
por: Wang, Shuo, et al.
Publicado: (2020)

Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm
por: Jadli, Anshul S., et al.
Publicado: (2022)

Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells
por: Zheng, Hui, et al.
Publicado: (2022)

Heterogeneity of Aortic Smooth Muscle Cells: A Determinant for Regional Characteristics of Thoracic Aortic Aneurysms?
por: Sawada, Hisashi, et al.
Publicado: (2018)

Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility
por: Busch, Albert, et al.
Publicado: (2021)

Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
por: Ito, Sohei, et al.
Publicado: (2022)

Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production
por: Xue, Ming, et al.
Publicado: (2019)

Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1
por: Qian, Weiyi, et al.
Publicado: (2022)

Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis
por: Gao, Jianing, et al.
Publicado: (2022)

Human Umbilical Cord Mesenchymal Stem Cells Attenuate Abdominal Aortic Aneurysm Progression in Sprague-Dawley Rats: Implication of Vascular Smooth Muscle Cell Phenotypic Modulation
por: Wen, Hao, et al.
Publicado: (2020)

Syndecan-1 Regulates Vascular Smooth Muscle Cell Phenotype
por: Chaterji, Somali, et al.
Publicado: (2014)

Targeting smooth muscle cell phenotypic switching in vascular disease
por: Chakraborty, Raja, et al.
Publicado: (2021)

Role of Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis
por: Ashraf, Jasni Viralippurath, et al.
Publicado: (2021)

Vascular smooth muscle cell phenotype switching in carotid atherosclerosis
por: Chou, Elizabeth L., et al.
Publicado: (2021)

Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases
por: Tang, Hao-Yue, et al.
Publicado: (2022)

Trimethylamine N-Oxide Promotes Abdominal Aortic Aneurysm Formation by Aggravating Aortic Smooth Muscle Cell Senescence in Mice
por: Hu, Jiaxin, et al.
Publicado: (2022)

Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases
por: Worssam, Matthew D., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_57v07bm5rueui5jbnv6aj6maac