The brain-penetrant cell-cycle inhibitor p28 sensitizes brain metastases to DNA-damaging agents

BACKGROUND: Brain metastases (BMs), the most common tumors of the central nervous system, are life-threatening with a dismal prognosis. The major challenges to developing effective treatments for BMs are the limited abilities of drugs to target tumors and to cross the blood-brain barrier (BBB). We a...

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Detalles Bibliográficos
Autores principales: Mander, Sunam, Gorman, Gregory S, Coward, Lori U, Christov, Konstantin, Green, Albert, Das Gupta, Tapas K, Yamada, Tohru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184511/
https://www.ncbi.nlm.nih.gov/pubmed/37197737
http://dx.doi.org/10.1093/noajnl/vdad042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184511/
https://www.ncbi.nlm.nih.gov/pubmed/37197737
http://dx.doi.org/10.1093/noajnl/vdad042

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