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Development of an Anti-canine PD-L1 Antibody and Caninized PD-L1 Mouse Model as Translational Research Tools for the Study of Immunotherapy in Humans

Immune checkpoint blockade therapy, one of the most promising cancer immunotherapies, has shown remarkable clinical impact in multiple cancer types. Despite the recent success of immune checkpoint blockade therapy, however, the response rates in patients with cancer are limited (∼20%–40%). To improv...

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Detalles Bibliográficos
Autores principales: Oh, Wonkyung, Kim, Alyssa Min Jung, Dhawan, Deepika, Kirkham, Perry M., Ostafe, Raluca, Franco, Jackeline, Aryal, Uma K., Carnahan, Robert H., Patsekin, Valery, Robinson, J. Paul, Knapp, Deborah W., Lim, Seung-Oe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184575/
https://www.ncbi.nlm.nih.gov/pubmed/37377896
http://dx.doi.org/10.1158/2767-9764.CRC-22-0468