Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice

Female bias is highly prevalent in conditions such as adrenal cortex hyperplasia and neoplasia, but the reasons behind this phenomenon are poorly understood. In this study, we show that overexpression of the secreted WNT agonist R-spondin 1 (RSPO1) leads to ectopic activation of WNT/β-catenin signal...

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Detalles Bibliográficos
Autores principales: Lyraki, Rodanthi, Grabek, Anaëlle, Tison, Amélie, Weerasinghe Arachchige, Lahiru Chamara, Peitzsch, Mirko, Bechmann, Nicole, Youssef, Sameh A., de Bruin, Alain, Bakker, Elvira R. M., Claessens, Frank, Chaboissier, Marie-Christine, Schedl, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184674/
https://www.ncbi.nlm.nih.gov/pubmed/37102205
http://dx.doi.org/10.1242/dmm.050053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184674/
https://www.ncbi.nlm.nih.gov/pubmed/37102205
http://dx.doi.org/10.1242/dmm.050053

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