Mechanisms that promote the evolution of cross-reactive antibodies upon vaccination with designed influenza immunogens

Immunogens that elicit broadly neutralizing antibodies targeting the conserved receptor-binding site (RBS) on influenza hemagglutinin may serve as candidates for a universal influenza vaccine. Here, we develop a computational model to interrogate antibody evolution by affinity maturation after immun...

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Detalles Bibliográficos
Autores principales: Yang, Leerang, Caradonna, Timothy M., Schmidt, Aaron G., Chakraborty, Arup K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184763/
https://www.ncbi.nlm.nih.gov/pubmed/36867533
http://dx.doi.org/10.1016/j.celrep.2023.112160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184763/
https://www.ncbi.nlm.nih.gov/pubmed/36867533
http://dx.doi.org/10.1016/j.celrep.2023.112160

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