The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes

Anti-apoptotic proteins such as BCL-X(L) promote cell survival by sequestering pro-apoptotic BCL-2 family members, an activity that frequently contributes to tumorigenesis. Thus, the development of small-molecule inhibitors for anti-apoptotic proteins, termed BH3-mimetics, is revolutionizing how we...

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Detalles Bibliográficos
Autores principales: Pemberton, James M, Nguyen, Dang, Osterlund, Elizabeth J, Schormann, Wiebke, Pogmore, Justin P, Hirmiz, Nehad, Leber, Brian, Andrews, David W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185343/
https://www.ncbi.nlm.nih.gov/pubmed/37078707
http://dx.doi.org/10.7554/eLife.88329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185343/
https://www.ncbi.nlm.nih.gov/pubmed/37078707
http://dx.doi.org/10.7554/eLife.88329

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