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The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes

Anti-apoptotic proteins such as BCL-X(L) promote cell survival by sequestering pro-apoptotic BCL-2 family members, an activity that frequently contributes to tumorigenesis. Thus, the development of small-molecule inhibitors for anti-apoptotic proteins, termed BH3-mimetics, is revolutionizing how we...

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Detalles Bibliográficos
Autores principales:	Pemberton, James M, Nguyen, Dang, Osterlund, Elizabeth J, Schormann, Wiebke, Pogmore, Justin P, Hirmiz, Nehad, Leber, Brian, Andrews, David W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185343/ https://www.ncbi.nlm.nih.gov/pubmed/37078707 http://dx.doi.org/10.7554/eLife.88329

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