Predicting allosteric pockets in protein biological assemblages

MOTIVATION: Allostery enables changes to the dynamic behavior of a protein at distant positions induced by binding. Here, we present APOP, a new allosteric pocket prediction method, which perturbs the pockets formed in the structure by stiffening pairwise interactions in the elastic network across t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Ambuj, Kaynak, Burak T, Dorman, Karin S, Doruker, Pemra, Jernigan, Robert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185404/
https://www.ncbi.nlm.nih.gov/pubmed/37115636
http://dx.doi.org/10.1093/bioinformatics/btad275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185404/
https://www.ncbi.nlm.nih.gov/pubmed/37115636
http://dx.doi.org/10.1093/bioinformatics/btad275

Ejemplares similares