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Predicting allosteric pockets in protein biological assemblages

MOTIVATION: Allostery enables changes to the dynamic behavior of a protein at distant positions induced by binding. Here, we present APOP, a new allosteric pocket prediction method, which perturbs the pockets formed in the structure by stiffening pairwise interactions in the elastic network across t...

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Detalles Bibliográficos
Autores principales:	Kumar, Ambuj, Kaynak, Burak T, Dorman, Karin S, Doruker, Pemra, Jernigan, Robert L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185404/ https://www.ncbi.nlm.nih.gov/pubmed/37115636 http://dx.doi.org/10.1093/bioinformatics/btad275

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