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Recombinant human DNase-I improves acute respiratory distress syndrome via neutrophil extracellular trap degradation

BACKGROUND: Respiratory failure is the primary cause of death in patients with COVID-19, whereas coagulopathy is associated with excessive inflammation and multiorgan failure. Neutrophil extracellular traps (NETs) may exacerbate inflammation and provide a scaffold for thrombus formation. OBJECTIVES:...

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Detalles Bibliográficos
Autores principales: Jarrahi, Abbas, Khodadadi, Hesam, Moore, Nicholas S., Lu, Yujiao, Awad, Mohamed E., Salles, Evila L., Vaibhav, Kumar, Baban, Babak, Dhandapani, Krishnan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185489/
https://www.ncbi.nlm.nih.gov/pubmed/37196848
http://dx.doi.org/10.1016/j.jtha.2023.04.044