Identification of SARS-CoV-2 PLpro and 3CLpro human proteome substrates using substrate phage display coupled with protein network analysis

Viral proteases play key roles in viral replication, and they also facilitate immune escape by proteolyzing diverse target proteins. Deep profiling of viral protease substrates in host cells is beneficial for understanding viral pathogenesis and for antiviral drug discovery. Here, we utilized substr...

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Detalles Bibliográficos
Autores principales: Zhao, Kai, Li, Yini, Guo, Mengzhun, Ma, Lijia, Dang, Bobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185492/
https://www.ncbi.nlm.nih.gov/pubmed/37201587
http://dx.doi.org/10.1016/j.jbc.2023.104831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185492/
https://www.ncbi.nlm.nih.gov/pubmed/37201587
http://dx.doi.org/10.1016/j.jbc.2023.104831

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