KCC2 downregulation after sciatic nerve injury enhances motor function recovery

Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl(−)] and depolarized GABAergic signaling. This phenotype mirrors immature neurons wherein GABA-evoked depolarizations facilitate neuronal circuit maturation. Thus, injury-induced KCC2...

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Detalles Bibliográficos
Autores principales: Cheung, Dennis Lawrence, Toda, Takuya, Narushima, Madoka, Eto, Kei, Takayama, Chitoshi, Ooba, Tatsuko, Wake, Hiroaki, Moorhouse, Andrew John, Nabekura, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185507/
https://www.ncbi.nlm.nih.gov/pubmed/37188694
http://dx.doi.org/10.1038/s41598-023-34701-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185507/
https://www.ncbi.nlm.nih.gov/pubmed/37188694
http://dx.doi.org/10.1038/s41598-023-34701-y

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