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Mutational signatures association with replication timing in normal cells reveals similarities and differences with matched cancer tissues

Mutational signatures’ association with replication timing (RT) has been studied in cancer samples, but the RT distribution of somatic mutations in non-cancerous cells was only minimally explored. Here, we performed comprehensive analyses of mutational signatures in 2.9 million somatic mutations acr...

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Detalles Bibliográficos
Autores principales: Yaacov, Adar, Rosenberg, Shai, Simon, Itamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185532/
https://www.ncbi.nlm.nih.gov/pubmed/37188696
http://dx.doi.org/10.1038/s41598-023-34631-9