α-Synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased lipid-associated fibril uptake into iPSC-derived neurons

Monomeric alpha-synuclein (aSyn) is a well characterised protein that importantly binds to lipids. aSyn monomers assemble into amyloid fibrils which are localised to lipids and organelles in insoluble structures found in Parkinson’s disease patient’s brains. Previous work to address pathological aSy...

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Detalles Bibliográficos
Autores principales: Stephens, Amberley D., Villegas, Ana Fernandez, Chung, Chyi Wei, Vanderpoorten, Oliver, Pinotsi, Dorothea, Mela, Ioanna, Ward, Edward, McCoy, Thomas M., Cubitt, Robert, Routh, Alexander F., Kaminski, Clemens F., Kaminski Schierle, Gabriele S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185682/
https://www.ncbi.nlm.nih.gov/pubmed/37188797
http://dx.doi.org/10.1038/s42003-023-04884-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185682/
https://www.ncbi.nlm.nih.gov/pubmed/37188797
http://dx.doi.org/10.1038/s42003-023-04884-1

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