Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy

The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy. We screened a library of Fas-TNFR proteins identifying several novel chimeras tha...

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Detalles Bibliográficos
Autores principales: McKenzie, Callum, El-Kholy, Mohamed, Parekh, Farhaan, Robson, Mathew, Lamb, Katarina, Allen, Christopher, Sillibourne, James, Cordoba, Shaun, Thomas, Simon, Pule, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185706/
https://www.ncbi.nlm.nih.gov/pubmed/37200859
http://dx.doi.org/10.1016/j.omtn.2023.04.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185706/
https://www.ncbi.nlm.nih.gov/pubmed/37200859
http://dx.doi.org/10.1016/j.omtn.2023.04.017

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