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Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy
The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy. We screened a library of Fas-TNFR proteins identifying several novel chimeras tha...
Autores principales: | McKenzie, Callum, El-Kholy, Mohamed, Parekh, Farhaan, Robson, Mathew, Lamb, Katarina, Allen, Christopher, Sillibourne, James, Cordoba, Shaun, Thomas, Simon, Pule, Martin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185706/ https://www.ncbi.nlm.nih.gov/pubmed/37200859 http://dx.doi.org/10.1016/j.omtn.2023.04.017 |
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