In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers

Background: Loss of function mutation in FLG is the major genetic risk factor for atopic dermatitis (AD) and other allergic manifestations. Presently, little is known about the cellular turnover and stability of profilaggrin, the protein encoded by FLG. Since ubiquitination directly regulates the ce...

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Detalles Bibliográficos
Autores principales: Paul, Argho Aninda, Szulc, Natalia A., Kobiela, Adrian, Brown, Sara J., Pokrzywa, Wojciech, Gutowska-Owsiak, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185843/
https://www.ncbi.nlm.nih.gov/pubmed/37200867
http://dx.doi.org/10.3389/fmolb.2023.1105678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185843/
https://www.ncbi.nlm.nih.gov/pubmed/37200867
http://dx.doi.org/10.3389/fmolb.2023.1105678

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