Metformin attenuates high-fat diet induced metabolic syndrome related osteoarthritis through inhibition of prostaglandins

High-fat diet induces bone marrow inflammation and osteoarthritis phenotype in knee joint, but the underlying mechanisms is unknown. Here, we report that high-fat diet induces aberrant bone formation and cartilage degeneration in knee joint. Mechanistically, a high-fat diet increases the number of m...

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Detalles Bibliográficos
Autores principales: Liu, Xiaonan, Guo, Qiaoyue, Wang, Lei, Gu, Yiru, Meng, Senxiong, Gu, Yuan, Yu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185907/
https://www.ncbi.nlm.nih.gov/pubmed/37200628
http://dx.doi.org/10.3389/fcell.2023.1184524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185907/
https://www.ncbi.nlm.nih.gov/pubmed/37200628
http://dx.doi.org/10.3389/fcell.2023.1184524

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