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Metformin attenuates high-fat diet induced metabolic syndrome related osteoarthritis through inhibition of prostaglandins
High-fat diet induces bone marrow inflammation and osteoarthritis phenotype in knee joint, but the underlying mechanisms is unknown. Here, we report that high-fat diet induces aberrant bone formation and cartilage degeneration in knee joint. Mechanistically, a high-fat diet increases the number of m...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185907/ https://www.ncbi.nlm.nih.gov/pubmed/37200628 http://dx.doi.org/10.3389/fcell.2023.1184524 |