Cargando…
Protocol of a Phase II Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial of S-Adenosyl Methionine in Participants with Mild Cognitive Impairment or Dementia Due to Alzheimer’s Disease
BACKGROUND: S-adenosyl methionine (SAMe) is a pivotal metabolite in multiple pathways required for neuronal homeostasis, several of which are compromised in Alzheimer’s disease (AD). Correction of the SAMe deficiency that is characteristic of the AD brain may attenuate or prevent pathological proces...
Autores principales: | Holper, Sarah, Watson, R., Churilov, L., Yates, P., Lim, Y. Y., Barnham, K. J., Yassi, N. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186290/ https://www.ncbi.nlm.nih.gov/pubmed/37874102 http://dx.doi.org/10.14283/jpad.2023.55 |
Ejemplares similares
-
Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases
por: Rudenko, A. Yu., et al.
Publicado: (2022) -
Role of betaine in improving the antidepressant effect of S-adenosyl-methionine in patients with mild-to-moderate depression
por: Di Pierro, Francesco, et al.
Publicado: (2015) -
S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
por: Tsikas, Dimitrios, et al.
Publicado: (2017) -
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
por: Obata, Fumiaki, et al.
Publicado: (2015) -
Structural Mechanism of S-Adenosyl Methionine Binding to Catechol O-Methyltransferase
por: Tsao, Douglas, et al.
Publicado: (2011)