Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

The discovery and characterization of antigen-specific CD8(+) T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers. We adapt single-chain trimer (SCT) technologies into a high throughput platform for pMHC library generation, showing that hundre...

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Detalles Bibliográficos
Autores principales: Chour, William, Choi, Jongchan, Xie, Jingyi, Chaffee, Mary E., Schmitt, Thomas M., Finton, Kathryn, DeLucia, Diana C., Xu, Alexander M., Su, Yapeng, Chen, Daniel G., Zhang, Rongyu, Yuan, Dan, Hong, Sunga, Ng, Alphonsus H. C., Butler, Jonah Z., Edmark, Rick A., Jones, Lesley C., Murray, Kim M., Peng, Songming, Li, Guideng, Strong, Roland K., Lee, John K., Goldman, Jason D., Greenberg, Philip D., Heath, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186326/
https://www.ncbi.nlm.nih.gov/pubmed/37193826
http://dx.doi.org/10.1038/s42003-023-04899-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186326/
https://www.ncbi.nlm.nih.gov/pubmed/37193826
http://dx.doi.org/10.1038/s42003-023-04899-8

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