Dual receptor T cells mediate effective antitumor immune responses via increased recognition of tumor antigens

BACKGROUND: Discovery that ~16% of T cells naturally co-express two T-cell receptor (TCR) clonotypes prompts examining the role of dual TCR cells in immune functions. METHODS: Using TCRα-reporter transgenic mice, enabling unambiguous identification of single-TCR and dual-TCR cells, we tested the rol...

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Detalles Bibliográficos
Autores principales: Jang, Hyun J, Caron, Christine, Lee, Calvin K, Wang, Lu, Jama, Burhan, Bui, Jack D, Morris, Gerald P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186424/
https://www.ncbi.nlm.nih.gov/pubmed/37188395
http://dx.doi.org/10.1136/jitc-2022-006472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186424/
https://www.ncbi.nlm.nih.gov/pubmed/37188395
http://dx.doi.org/10.1136/jitc-2022-006472

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