Neoadjuvant intratumoral influenza vaccine treatment in patients with proficient mismatch repair colorectal cancer leads to increased tumor infiltration of CD8+ T cells and upregulation of PD-L1: a phase 1/2 clinical trial

BACKGROUND: In colorectal cancer, the effects of immune checkpoint inhibitors are mostly limited to patients with deficient mismatch repair tumors, characterized by a high grade infiltration of CD8+T cells. Interventions aimed at increasing intratumoral CD8+T-cell infiltration in proficient mismatch...

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Detalles Bibliográficos
Autores principales: Gögenur, Mikail, Balsevicius, Lukas, Bulut, Mustafa, Colak, Nesibe, Justesen, Tobias Freyberg, Fiehn, Anne-Marie Kanstrup, Jensen, Marianne Bøgevang, Høst-Rasmussen, Kathrine, Cappelen, Britt, Gaggar, Shruti, Tajik, Asma, Zahid, Jawad Ahmad, Bennedsen, Astrid Louise Bjørn, D’Ondes, Tommaso Del Buono, Raskov, Hans, Sækmose, Susanne Gjørup, Hansen, Lasse Bremholm, Salanti, Ali, Brix, Susanne, Gögenur, Ismail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186478/
https://www.ncbi.nlm.nih.gov/pubmed/37172969
http://dx.doi.org/10.1136/jitc-2023-006774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186478/
https://www.ncbi.nlm.nih.gov/pubmed/37172969
http://dx.doi.org/10.1136/jitc-2023-006774

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