Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics

The intestinal epithelium consists of cells derived from continuously cycling Lgr5(hi) intestinal stem cells (Lgr5(hi) ISCs) that mature developmentally in an ordered fashion as the cells progress along the crypt‐luminal axis. Perturbed function of Lgr5(hi) ISCs with aging is documented, but the con...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Jiahn, Houston, Michele, Wang, Ruixuan, Ye, Kenny, Li, Wenge, Zhang, Xusheng, Huffman, Derek M., Augenlicht, Leonard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186593/
https://www.ncbi.nlm.nih.gov/pubmed/36864750
http://dx.doi.org/10.1111/acel.13802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186593/
https://www.ncbi.nlm.nih.gov/pubmed/36864750
http://dx.doi.org/10.1111/acel.13802

Ejemplares similares