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Oxidative stress impairs the Nur77‐Sirt1 axis resulting in a decline in organism homeostasis during aging
Sirt1 is an NAD(+)‐dependent deacetylase that protects against premature aging and cell senescence. Aging accompanied by oxidative stress leads to a decrease in Sirt1 levels and activity, but the regulatory mechanism that connects these events remains unclear. Here, we reported that Nur77, which sha...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186606/ https://www.ncbi.nlm.nih.gov/pubmed/36883265 http://dx.doi.org/10.1111/acel.13812 |