Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease

Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild–moderate Alzheimer’s disease (AD) treated with nilotinib (versus placebo) for 12 months showed reduction...

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Detalles Bibliográficos
Autores principales: Stevenson, Max, Varghese, Rency, Hebron, Michaeline L., Liu, Xiaoguang, Ratliff, Nick, Smith, Amelia, Turner, R. Scott, Moussa, Charbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186647/
https://www.ncbi.nlm.nih.gov/pubmed/37194065
http://dx.doi.org/10.1186/s12974-023-02802-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186647/
https://www.ncbi.nlm.nih.gov/pubmed/37194065
http://dx.doi.org/10.1186/s12974-023-02802-0

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