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α‐Synuclein Seed Amplification Assays in the Diagnosis of Synucleinopathies Using Cerebrospinal Fluid—A Systematic Review and Meta‐Analysis

BACKGROUND: Real‐time quaking‐induced conversion (RT‐QuIC) and protein misfolding cyclic amplification (PMCA) have been developed to detect minute amounts of amyloidogenic proteins via amplification techniques and have been used to detect misfolded α‐synuclein (αSyn) aggregates in the cerebrospinal...

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Detalles Bibliográficos
Autores principales: Grossauer, Anna, Hemicker, Greta, Krismer, Florian, Peball, Marina, Djamshidian, Atbin, Poewe, Werner, Seppi, Klaus, Heim, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187020/
https://www.ncbi.nlm.nih.gov/pubmed/37205253
http://dx.doi.org/10.1002/mdc3.13710