Curcumin analogues exert potent inhibition on human and rat gonadal 3β-hydroxysteroid dehydrogenases as potential therapeutic agents: structure-activity relationship and in silico docking

Curcuminoids are functional food additives, and the effect on gonadal hormone biosynthesis remains unclear. Gonads contain 3β-hydroxysteroid dehydrogenase isoforms, h3β-HSD2 (humans) and r3β-HSD1 (rats), which catalyse pregnenolone into progesterone. The potency and mechanisms of curcuminoids to inh...

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Detalles Bibliográficos
Autores principales: Qiao, Xinyi, Ye, Lei, Lu, Jialin, Pan, Chengshuang, Fei, Qianjin, Zhu, Yang, Li, Huitao, Lin, Han, Ge, Ren-shan, Wang, Yiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187107/
https://www.ncbi.nlm.nih.gov/pubmed/37184069
http://dx.doi.org/10.1080/14756366.2023.2205052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187107/
https://www.ncbi.nlm.nih.gov/pubmed/37184069
http://dx.doi.org/10.1080/14756366.2023.2205052

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