Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice reportedly promotes resistance to hepatic steatosis and inflamma...

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Detalles Bibliográficos
Autores principales: Min, Kyounghee, Yenilmez, Batuhan, Kelly, Mark, Echeverria, Dimas, Elleby, Michael, Lifshitz, Lawrence M., Raymond, Naideline, Tsagkaraki, Emmanouela, Harney, Shauna M., DiMarzio, Chloe, Wang, Hui, McHugh, Nicholas, Bramato, Brianna, Morrision, Brett, Rothstein, Jeffery D., Khvorova, Anastasia, Czech, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187148/
https://www.ncbi.nlm.nih.gov/pubmed/37205462
http://dx.doi.org/10.1101/2023.05.03.539244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187148/
https://www.ncbi.nlm.nih.gov/pubmed/37205462
http://dx.doi.org/10.1101/2023.05.03.539244

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