GPCR binding and JNK3 activation by arrestin-3 have different structural requirements

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Arrestins bind active phosphorylated G protein-coupled receptors (GPCRs). Among the four mammalian subtypes, only arrestin-3 facilitates the activation of JNK3 in cells. In available structures, Lys-295 in the lariat loop of arrestin-3 and its homologue Lys-294 in arrestin-2 directly interact with t...

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Detalles Bibliográficos
Autores principales: Zheng, Chen, Weinstein, Liana D., Nguyen, Kevin K., Grewal, Abhijeet, Gurevich, Eugenia V., Gurevich, Vsevolod V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187157/
https://www.ncbi.nlm.nih.gov/pubmed/37205393
http://dx.doi.org/10.1101/2023.05.01.538990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187157/
https://www.ncbi.nlm.nih.gov/pubmed/37205393
http://dx.doi.org/10.1101/2023.05.01.538990

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