Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function

The clinical response to adoptive T cell therapies is strongly associated with transcriptional and epigenetic state. Thus, technologies to discover regulators of T cell gene networks and their corresponding phenotypes have great potential to improve the efficacy of T cell therapies. We developed poo...

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Detalles Bibliográficos
Autores principales: McCutcheon, Sean R., Swartz, Adam M., Brown, Michael C., Barrera, Alejandro, Amador, Christian McRoberts, Siklenka, Keith, Humayun, Lucas, Isaacs, James M., Reddy, Timothy E., Nair, Smita, Antonia, Scott, Gersbach, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187198/
https://www.ncbi.nlm.nih.gov/pubmed/37205457
http://dx.doi.org/10.1101/2023.05.01.538906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187198/
https://www.ncbi.nlm.nih.gov/pubmed/37205457
http://dx.doi.org/10.1101/2023.05.01.538906

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