Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ

The nine different membrane-anchored adenylyl cyclase isoforms (AC1–9) in mammals are stimulated by the heterotrimeric G protein Gα(s), but their response to Gβγ regulation is isoform-specific. For example, AC5 is conditionally activated by Gβγ. Here, we report cryo-EM structures of ligand-free AC5...

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Detalles Bibliográficos
Autores principales: Yen, Yu-Chen, Li, Yong, Chen, Chun-Liang, Klose, Thomas, Watts, Val J, Dessauer, Carmen W, Tesmer, John J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187219/
https://www.ncbi.nlm.nih.gov/pubmed/37205557
http://dx.doi.org/10.1101/2023.05.02.539090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187219/
https://www.ncbi.nlm.nih.gov/pubmed/37205557
http://dx.doi.org/10.1101/2023.05.02.539090

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