Interface-acting nucleotide controls polymerization dynamics at microtubule plus- and minus-ends

GTP-tubulin is preferentially incorporated at growing microtubule ends, but the biochemical mechanism by which the bound nucleotide regulates the strength of tubulin:tubulin interactions is debated. The ‘self-acting’ (cis) model posits that the nucleotide (GTP or GDP) bound to a particular tubulin d...

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Detalles Bibliográficos
Autores principales: McCormick, Lauren A, Cleary, Joseph M, Hancock, William O, Rice, Luke M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187237/
https://www.ncbi.nlm.nih.gov/pubmed/37205370
http://dx.doi.org/10.1101/2023.05.03.539131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187237/
https://www.ncbi.nlm.nih.gov/pubmed/37205370
http://dx.doi.org/10.1101/2023.05.03.539131

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