Syntheses of Pyrimidine-Modified Seleno-DNAs as Stable Antisense Molecules

Chemically modified antisense oligonucleotides (ASO) currently in pre-clinical and clinical experiments mainly focus on the 2’-position derivatizations to enhance stability and targeting affinity. Considering the possible incompatibility of 2’-modifications with RNase H stimulation and activity, we...

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Detalles Bibliográficos
Autores principales: Fang, Ziyuan, Dantsu, Yuliya, Chen, Cen, Zhang, Wen, Huang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187239/
https://www.ncbi.nlm.nih.gov/pubmed/37205589
http://dx.doi.org/10.1101/2023.05.02.539140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187239/
https://www.ncbi.nlm.nih.gov/pubmed/37205589
http://dx.doi.org/10.1101/2023.05.02.539140

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