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Syntheses of Pyrimidine-Modified Seleno-DNAs as Stable Antisense Molecules
Chemically modified antisense oligonucleotides (ASO) currently in pre-clinical and clinical experiments mainly focus on the 2’-position derivatizations to enhance stability and targeting affinity. Considering the possible incompatibility of 2’-modifications with RNase H stimulation and activity, we...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187239/ https://www.ncbi.nlm.nih.gov/pubmed/37205589 http://dx.doi.org/10.1101/2023.05.02.539140 |