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Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant

The mitochondrial phospholipid cardiolipin (CL) promotes bioenergetics via oxidative phosphorylation (OXPHOS). Three tightly bound CLs are evolutionarily conserved in the ADP/ATP carrier (AAC in yeast; adenine nucleotide translocator, ANT in mammals) which resides in the inner mitochondrial membrane...

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Detalles Bibliográficos
Autores principales: Senoo, Nanami, Chinthapalli, Dinesh K., Baile, Matthew G., Golla, Vinaya K., Saha, Bodhisattwa, Ogunbona, Oluwaseun B., Saba, James A., Munteanu, Teona, Valdez, Yllka, Whited, Kevin, Chorev, Dror, Alder, Nathan N., May, Eric R., Robinson, Carol V., Claypool, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187269/
https://www.ncbi.nlm.nih.gov/pubmed/37205478
http://dx.doi.org/10.1101/2023.05.05.539595