ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex

Hyperexcitability in the orbitofrontal cortex (OFC) is a key clinical feature of anhedonic domains of Major Depressive Disorder (MDD). However, the cellular and molecular substrates underlying this dysfunction remain unknown. Here, cell-population-specific chromatin accessibility profiling in human...

Descripción completa

Detalles Bibliográficos
Autores principales: Fulton, Sasha L., Bendl, Jaroslav, Gameiro-Ros, Isabel, Fullard, John F., Al-Kachak, Amni, Lepack, Ashley E., Stewart, Andrew F., Singh, Sumnima, Poller, Wolfram C., Bastle, Ryan M., Hauberg, Mads E., Fakira, Amanda K., Chen, Min, Cuttoli, Romain Durand-de, Cathomas, Flurin, Ramakrishnan, Aarthi, Gleason, Kelly, Shen, Li, Tamminga, Carol A., Milosevic, Ana, Russo, Scott J., Swirski, Filip, Blitzer, Robert D., Slesinger, Paul A., Roussos, Panos, Maze, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187272/
https://www.ncbi.nlm.nih.gov/pubmed/37205394
http://dx.doi.org/10.1101/2023.05.04.539425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187272/
https://www.ncbi.nlm.nih.gov/pubmed/37205394
http://dx.doi.org/10.1101/2023.05.04.539425

Ejemplares similares