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Human macroH2A1 drives nucleosome dephasing and genome instability in histone-humanized yeast

In addition to replicative histones, eukaryotic genomes encode a repertoire of non-replicative variant histones providing additional layers of structural and epigenetic regulation. Here, we systematically replaced individual replicative human histones with non-replicative human variant histones usin...

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Detalles Bibliográficos
Autores principales: Haase, Max A. B., Lazar-Stefanita, Luciana, Ólafsson, Guðjón, Wudzinska, Aleksandra, Shen, Michael J., Truong, David M., Boeke, Jef D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187286/
https://www.ncbi.nlm.nih.gov/pubmed/37205538
http://dx.doi.org/10.1101/2023.05.06.538725