Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ

The conversion of PIP2 to PIP3 by phosphoinositide 3-kinase γ (PI3Kγ) is a critical step in neutrophil chemotaxis and is essential for metastasis in many types of cancer. PI3Kγ is activated via directed interaction with Gβγ heterodimers released from cell-surface G protein-coupled receptors (GPCRs)...

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Detalles Bibliográficos
Autores principales: Chen, Chun-Liang, Syahirah, Ramizah, Ravala, Sandeep K., Yen, Yu-Chen, Klose, Thomas, Deng, Qing, Tesmer, John J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187307/
https://www.ncbi.nlm.nih.gov/pubmed/37205329
http://dx.doi.org/10.1101/2023.05.04.539492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187307/
https://www.ncbi.nlm.nih.gov/pubmed/37205329
http://dx.doi.org/10.1101/2023.05.04.539492

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