Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer

The nutrient status of the tumor microenvironment has major impacts on cell growth. Under nutrient depletion, asparagine synthetase (ASNS)-mediated asparagine production increases to sustain cell survival. G protein-coupled estrogen receptor-1 (GPER1) signaling converges via cAMP/PI3K/AKT with KRAS...

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Detalles Bibliográficos
Autores principales: Lu, Lingeng, Zhang, Qian, Shen, Xinyi, Zhen, Pinyi, Marin, Audrey, Garcia-Milian, Rolando, Roper, Jatin, Khan, Sajid A., Johnson, Caroline H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187315/
https://www.ncbi.nlm.nih.gov/pubmed/37205388
http://dx.doi.org/10.1101/2023.05.05.539577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187315/
https://www.ncbi.nlm.nih.gov/pubmed/37205388
http://dx.doi.org/10.1101/2023.05.05.539577

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