Cargando…

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer

The nutrient status of the tumor microenvironment has major impacts on cell growth. Under nutrient depletion, asparagine synthetase (ASNS)-mediated asparagine production increases to sustain cell survival. G protein-coupled estrogen receptor-1 (GPER1) signaling converges via cAMP/PI3K/AKT with KRAS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Lingeng, Zhang, Qian, Shen, Xinyi, Zhen, Pinyi, Marin, Audrey, Garcia-Milian, Rolando, Roper, Jatin, Khan, Sajid A., Johnson, Caroline H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187315/ https://www.ncbi.nlm.nih.gov/pubmed/37205388 http://dx.doi.org/10.1101/2023.05.05.539577

Ejemplares similares

Primary cilia sense glutamine availability and respond via asparagine synthetase
por: Steidl, Maria Elena, et al.
Publicado: (2023)

Cereal asparagine synthetase genes
por: Raffan, Sarah, et al.
Publicado: (2020)

Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency
por: Staklinski, Stephen J., et al.
Publicado: (2022)

Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
por: Loureiro, Inês, et al.
Publicado: (2013)

Filamentation of asparagine synthetase in Saccharomyces cerevisiae
por: Zhang, Shanshan, et al.
Publicado: (2018)

Correction: Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine
por: Loureiro, Inês, et al.
Publicado: (2013)

Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells
por: Chang, Mario C., et al.
Publicado: (2023)

Novel Insights into Regulation of Asparagine Synthetase in Conifers
por: Canales, Javier, et al.
Publicado: (2012)

Human asparagine synthetase associates with the mitotic spindle
por: Noree, Chalongrat, et al.
Publicado: (2018)

Coordination of asparagine uptake and asparagine synthetase expression modulates CD8(+) T cell activation
por: Hope, Helen Carrasco, et al.
Publicado: (2021)

Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase()()
por: Toda, Kosuke, et al.
Publicado: (2016)

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia
por: Chiu, Martina, et al.
Publicado: (2020)

Asparagine synthetase deficiency: A novel case with an unusual molecular mechanism
por: Faoucher, Marie, et al.
Publicado: (2019)

Analysis of Enzyme Activity and Cellular Function for the N80S and S480F Asparagine Synthetase Variants Expressed in a Child with Asparagine Synthetase Deficiency
por: Staklinski, Stephen J., et al.
Publicado: (2022)

Asparagine, colorectal cancer, and the role of sex, genes, microbes, and diet: A narrative review
por: Shen, Xinyi, et al.
Publicado: (2022)

Novel Mutations in the Asparagine Synthetase Gene (ASNS) Associated With Microcephaly
por: Schleinitz, Dorit, et al.
Publicado: (2018)

Genomic, Biochemical, and Modeling Analyses of Asparagine Synthetases from Wheat
por: Xu, Hongwei, et al.
Publicado: (2018)

Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines
por: Staklinski, Stephen J., et al.
Publicado: (2023)

Severe Microcephaly and Metabolic Epilepsy due to Asparagine Synthetase Deficiency
por: Saini, Arushi G., et al.
Publicado: (2023)

Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma
por: Fu, Yong, et al.
Publicado: (2021)

Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study
por: Shen, Xinyi, et al.
Publicado: (2022)

Saccharomyces cerevisiae ASN1 and ASN2 are asparagine synthetase paralogs that have diverged in their ability to polymerize in response to nutrient stress
por: Noree, Chalongrat, et al.
Publicado: (2019)

Food safety: Structure and expression of the asparagine synthetase gene family of wheat
por: Gao, Runhong, et al.
Publicado: (2016)

Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity
por: Faria, Joana, et al.
Publicado: (2016)

Functional Research on Three Presumed Asparagine Synthetase Family Members in Poplar
por: Qu, Chunpu, et al.
Publicado: (2019)

Polymorphism in asparagine synthetase is associated with overall survival of hepatocellular carcinoma patients
por: Li, Wei, et al.
Publicado: (2017)

Asparagine Synthetase and Filamin A Have Different Roles in Ovarian Cancer
por: Zeng, Liang, et al.
Publicado: (2019)

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
por: Xie, Stanley C., et al.
Publicado: (2023)

Utility of AlphaMissense predictions in Asparagine Synthetase deficiency variant classification
por: Staklinski, Stephen J., et al.
Publicado: (2023)

Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling
por: Mukherjee, Amitava, et al.
Publicado: (2019)

Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells
por: Nishikawa, Gen, et al.
Publicado: (2022)

Wheat with greatly reduced accumulation of free asparagine in the grain, produced by CRISPR/Cas9 editing of asparagine synthetase gene TaASN2
por: Raffan, Sarah, et al.
Publicado: (2021)

The identification of new cytosolic glutamine synthetase and asparagine synthetase genes in barley (Hordeum vulgare L.), and their expression during leaf senescence
por: Avila-Ospina, Liliana, et al.
Publicado: (2015)

Nicotiana benthamiana asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway
por: Liu, Changyun, et al.
Publicado: (2021)

Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma
por: Zhang, B, et al.
Publicado: (2013)

A novel compound heterozygous missense mutation in ASNS broadens the spectrum of asparagine synthetase deficiency
por: Wang, Chun, et al.
Publicado: (2020)

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity
por: Zhu, Wen, et al.
Publicado: (2019)

Effects of A6E Mutation on Protein Expression and Supramolecular Assembly of Yeast Asparagine Synthetase
por: Surasiang, Thunyarat, et al.
Publicado: (2021)

Nuclear targeted Saccharomyces cerevisiae asparagine synthetases associate with the mitotic spindle regardless of their enzymatic activity
por: Noree, Chalongrat, et al.
Publicado: (2020)

Consumption of meat containing ractopamine might enhance tumor growth through induction of asparagine synthetase
por: Fan, Frank S.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o24b27k4p1uv00scfvq4pe6slo