The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity

Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i’s) in combination with chemotherapy have shown promising results in preclinical studies but minimal efficacy with substantial toxicity in clinical trials. To explore novel combinational str...

Descripción completa

Detalles Bibliográficos
Autores principales: Prasad, Chandra Bhushan, Oo, Adrian, Qiu, Zhaojun, Li, Na, Singh, Deepika, Xin, Xiwen, Cho, Young-Jae, Li, Zaibo, Zhang, Xiaoli, Yan, Chunhong, Zheng, Qingfei, Shao, Jimin, Wang, Qi-En, Kim, Baek, Zhang, Junran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187419/
https://www.ncbi.nlm.nih.gov/pubmed/37205570
http://dx.doi.org/10.21203/rs.3.rs-2814118/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187419/
https://www.ncbi.nlm.nih.gov/pubmed/37205570
http://dx.doi.org/10.21203/rs.3.rs-2814118/v1

Ejemplares similares